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BME Seminars - Didier Letourneur

Seminar announcement flyer

This week’s OpenYourMind seminar will be given by Didier Letourneur, Director of INSERM U1148 LVTS and leader of the Cardiovascular Bio-engineering team. The seminar will be held this Friday, 9/12/2016 between 1:30 pm and 3 pm in Amphi Fournel at ENSAM ParisTech (151, Boulevard de l’Hopital, 75013 Paris). The seminar topic will be “Design and in vivo Validations of Polysaccharide-based Nano/Micro/Macrosystems for Tissue Engineering and Molecular Imaging”. For more details, please refer to the attached abstract.

This presentation intends to present polysaccharide-based matrices for regenerative medicine and as drug delivery systems and targeted contrast agents for molecular imaging. One main challenge of tissue engineering is to create an optimal environment for growing therapeutic cells to regenerate damaged tissues. This environment can be reconstituted by using 3D matrices, in which cells can be organized into a tissue-like structure. We have prepared polysaccharide-based porous matrices having controlled pores and porosity for several cell types. These porous hydrogels made of natural biodegradable and biocompatible polysaccharides have architectural characteristics adapted to the cell culture in 3D. Further studies have demonstrated the performance of these matrices for tissue repair in vitro as well as in small and large animals. Examples for heart, vessel, and bone will be presented. Moreover, polysaccharide-based nano and microsystems were designed and used for the imaging of cardiovascular pathologies as targeted contrast agents for molecular imaging. Examples will be provided using several types of imaging modalities for thrombus detection. We will also present how to use nanomaterials for regenerative medicine.

Arts et Métiers ParisTech
Université Paris Descartes
Master BME Paris