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BME Seminars - Michael K. Skinner


This week, the BME seminars "Open Your Mind" will host a conference of Michael K Skinner (see attached flyer for a short bibliography) from the Washington State University. His talk will focus on: "Role of Environmentally Induced Epigenetic Transgenerational Inheritance in Disease and Evolutionary Biology".

The conference will take place on Friday 24th january at Arts et Métiers ParisTech, 151 boulevard de l’Hôpital, 75013 Paris, Amphi Pinel, from 13h30 to 15h00.

"Transgenerational effects of environmental toxicants significantly amplify the impact and health hazards of these compounds. One of the most sensitive periods to exposure is during embryonic gonadal sex determination when the germ line is undergoing epigenetic programming and DNA re-methylation. Previous studies have shown that toxicants can cause an increase in adult onset disease such as infertility, prostate, ovary and kidney disease, cancers and obesity. Interestingly, this effect is transgenerational (F1, F2, F3 and F4 generations) and hypothesized to be due to a permanent (imprinted) altered DNA methylation of the germ-line. The transgenerational epigenetic mechanism appears to involve the actions of an environmental compound at the time of sex determination to permanently alter the epigenetic (i.e. DNA methylation) programming of the germ line that then alters the transcriptomes of developing organs to induce disease development transgenerationally.  Recently a variety of different environmental compounds have been shown to induce this epigenetic transgenerational inheritance of disease including:  fungicide vinclozolin, plastics BPA and phthalates, pesticides, DDT, dioxin and hydrocarbons.  The suggestion that environmental factors can reprogram the germ line to induce epigenetic transgenerational inheritance of disease and phenotypic variation is a new paradigm in disease etiology that is also relevant to other areas of biology such as evolution.  "

Published on: 20 January 2014 19:53
Arts et Métiers ParisTech
Université Paris Descartes
Master BME Paris